鶴田 文憲 Fuminori Tsuruta (ftsuruta@biol.tsukuba.ac.jp)
1996 - 1998 東京都立大学大学院修士課程 理学研究科 化学専攻
1998 - 1999 持田製薬株式会社 総合研究所 研究員
2000 - 2003 東京大学大学院 工学系研究科博士課程 化学生命工学専攻
2003 - 2004 東京大学分子細胞生物学研究所 博士研究員
2004 - 2009 Stanford University School of Medicine,
Postdoctoral fellow (日本学術振興会 海外特別研究員)
2009 - 筑波大学 生命環境系 生物科学専攻 助教
＜発表論文＞
Myeloma overexpressed 2 (Myeov2) regulates L11 subnuclear localization through Nedd8 modification
Ebina M*, Tsuruta F*#, Katoh MC, Kigoshi Y, Someya A, Chiba T# (*co-first, #co-corresponding)
PLoS ONE 8:e65285 (2013)
Acetylation-Mediated Proteasomal Degradation of Core Histones during DNA Repair and Spermatogenesis
Qian MX, Pang Y, Liu CH, Haratake K, Du BY, Ji DY, Wang GF, Zhu QQ, Song W, Yu Y, Zhang XX, Huang HT, Miao S, Chen LB, Zhang ZH, Liang YN, Liu S, Cha H, Yang D, Zhai Y, Komatsu T, Tsuruta F, Li H, Cao C, Li Wei, Li GH, Cheng Y, Chiba T, Wang L, Goldberg AL, Shen Y,
Qui XB
Cell 153:1012-1024 (2013)
Competition between a-actinin and Ca2+-calmodulin controls surface retention of the L-type Ca2+ channel CaV1.2
Hall DD, Dai S, Tseng PY, Malik Z, Nguyen M, Matt L, Schnizler K, Shephard A, Mohapatra DP, Tsuruta F, Dolmetsch RE, Christel CJ, Lee A, Burette A, Weinberg RJ and Hell JW
Neuron 78:483-497 (2013)
Brap2 regulates temporal control of NF-kB localization mediated by inflammatory res
ponse
Takashima O*, Tsuruta F*, Kigoshi Y, Nakamura S, Kim J, Katoh MC, Fukuda T, Irie K, Chiba T. (*co-first)
PLoS ONE 8:e58911 (2013)
Cytoplasmic location of a1A voltage-gated calcium channel C-terminal fragment (Cav2.1-CTF) aggregate as sufficient to cause cell death
Takahashi M, Obayashi M, Ishiguro T, Sato N, Niimi Y, Ozaki K, Mogushi K, Mahmut Y, Tanaka H, Tsuruta F, Dolmetsch R, Yamada M, Takahashi H, Kato T, Mori O, Eishi Y, Mizusawa H, Ishikawa K.
PLoS ONE 8:e50121 (2013)
A novel NEDD8-binding protein modulates NF-kB signaling pathway
Takashima O, Tsuruta F, Ebina M, Kigoshi Y, Nakamura S, Chiba T.
Arthritis Res Ther. 14(Suppl 1)(2012)
The ubiquitin E3 ligase activity of Cul3-KLHL7 is attenuated by an autosomal dominant Retinitis Pigmentosa causative mutation.
Kigoshi Y, Tsuruta F, Chiba T
J.Biol.Chem. 286:33613-33621(2011)
The carboxy-terminal fragment of alpha(1A) calcium channel preferentially aggregates in the cytoplasm of human spinocerebellar ataxia type 6 Purkinje cells.
Ishiguro T, Ishikawa K, Takahashi M, Obayashi M, Amino T, Sato N, Sakamoto
M, Fujigasaki H, Tsuruta F, Dolmetsch R, Arai T, Sasaki H, Nagashima K, Kato T, Yamada M, Takahashi H, Hashizume Y, Mizusawa H.
Acta Neuropathol. 119:447-464 (2010)
PIKfyve regulates CaV1.2 degradation and prevents excitotoxic cell death
Tsuruta F, Green EM, Rousset M and Dolmetsch RE.
J.Cell.Biol. 187:279-294 (2009)
The C terminus of the L-type voltage-gated calcium channel CaV1.2 encodes a transcription factor.
Gomez-Ospina N, Tsuruta F, Barreto-Chang O, Hu L and Dolmetsch RE.
Cell 127:591-606 (2006)
JNK antagonizes Akt-mediated survival signals by phosphorylating 14-3-3.
Sunayama J, Tsuruta F, Masuyama N, and Gotoh Y.
J.Cell.Biol. 170:295-304 (2005)
JNK promotes Bax translocation to mitochondria through phosphorylation
of 14-3-3proteins.
Tsuruta F, Sunayama S, Mori Y, Hattori S, Shimizu S, Tsujimoto Y,
Yoshioka K, Masuyama N, and Gotoh Y.
EMBO J. 23:1889-99 (2004)
The phoshoatidylinositol 3-kinase (PI3K)-Akt pathway suppresses Bax translocation to mitochondria.
Tsuruta F, Masuyama N, and Gotoh Y.
J.Biol.Chem. 277:14040-7 (2002)
細胞生存シグナルと死シグナルのバランスによる生死決定機構
砂山潤、鶴田文憲、後藤由季子
実験医学 23(13): 2006-2011. 2005
生存シグナルとアポトーシスシグナルのクロストーク
鶴田文憲、増山典久、後藤由季子
実験医学 18(10):1384-1390, 2000
